This is a particularly challenging time for those people involved in research into antimicrobial agents and their role in combating microbial infection. It
has been noted that the antimicrobial resistance threat is a worldwide issue and is now a priority area for researchers. To date the main body of my research has focused on the antimicrobial
effects of manuka honey on potentially pathogenic healthcare/wound associated microorganisms. I have studied the cellular morphology, physiology, biofilm prevention/disruption,
adhesion/invasion, virulence expression and proteomic/genetic expression profiles of these organisms in response to varying treatments with honey. It is hoped that the data generated by the in vitro
models used to examine the features listed above, could give an insight into the mode of action of the novel antimicrobial agents tested and how these treatments could be applied in an appropriate
manner to real world situations.
In parallel to those studies I am exploring the capacity of manuka honey to potentiate antibiotics already in use, especially those which alone, now have reduced
efficacy. We are particularly interested in the way this work could be implicated in the progression of infection and have translational potential.
I am interested in partnerships with the commercial sector looking at ways of applying the in vitro results into a clinical setting.
Current areas of interest: Antimicrobial susceptibility testing, biofilms, synergy, proteomic/genomic analysis.